ChemDraw 20 

ChemDraw® Prime is your everyday work horse solution for saving time drawing and publishing your experiments.

From a simple drawing tool to a chemically intelligent application, ChemDraw® has evolved into the software chemists and research scientists rely on. Whether you are an experienced chemist or an aspiring one, ChemDraw® allows you to find your way around chemistry without having to master drawing.



Here are some of the key features with ChemDraw® Prime

Create molecules and reactions as fast as you can type. A navigation hotkey allows you to quickly select and jump from one molecule to another.

Chemical properties calculations:
Quickly calculate important properties like Molecular Weight, Exact Mass, Chemical Formula and Elemental Analysis but also display the stereochemistry of your molecules.

Structure and Reaction clean-up:
Do not worry about how your molecules and reactions look, a smart clean-up tool for molecules and reactions allows you to make them ready for publication and presentation prime time.



ChemDraw® Prime version 20

  • New Atom Hotkeys and New Molecule Hotkey!
    A new version of ChemDraw® is not complete without a new set of hotkey.

  • New Molecule HHh Hotkey “Enter” lets you activate the hotspot on a selected molecule without touching the mouse.

  • New Entries Include the sulfone group (“k”), the tert-Butyl group with 90° angles (“Shift+k” on primary carbon), and the wedged/hashed wedged gem-dimethyl group (“Shift+k” on secondary carbon).


System requirements

System Requirements for ChemOffice version 19.1


Hardware Component Minimum Specification Recommended Specification
Memory (RAM)

For 32-bit OS 1 GB

For 64-bit OS 2 GB

For 32-bit OS 1 GB

For 64-bit OS 2 GB

Processor 1.6 GHz or higher 3.0 GHz or higher dual core processor
Free Space Required on Hard Drive 300 MB - 1 GB (1 GB is for installing the full ChemOffice Professional). This is for installation only and does not include any creation/expansion of any databases. 10 GB
Screen resolution 1024 x 768 or higher 1024 x 768 or higher


Software Windows Macintosh (ChemDraw Only)
Operating System
  • Windows 7 Professional and Ultimate (32-bit)
  • Windows 7 Professional and Ultimate (64-bit)
  • Windows 8.1 (64-bit)
  • Windows 10 (64-bit)
    • Mac OS X 10.15
    • Mac OS X 10.14
Microsoft Office (Standard, Professional, or Enterprise)

Microsoft Office 2016 (32-bit and 64-bit)*1

  • Microsoft Office 2019 (32-bit and 64-bit)*1
  • Office 365*1

*1 The latest update used for testing is 2002 (12527.20278).

Note: We test with the latest versions of MS Office available at the time, but that is no guarantee of full compatibly with future updates.

  • Microsoft Office 2016*2
  • Microsoft Office 2019*2
  • Office 365*2

*2 The latest update used for testing is 16.35 (20030802).

.Net Framework .Net Framework 4.x N/A
Browser ActiveX controls: Microsoft Internet Explorer 11.x (32-bit and 64-bit)


Note: The ChemDraw & Chem3D Plugins are no longer part of any ChemOffice/ChemDraw package. The ChemDraw & Chem3D ActiveX controls are still included with windows packages.

Product Compatibility

ChemDraw / ChemOffice 19.1.1 is qualified against the following:

Windows 7 Professional and Ultimate (32-bit and 64-bit)
Windows 8.1 (64-bit)
Windows 10 (64-bit)
Microsoft Office 2016
Microsoft Office 2019
Microsoft Office 365
Mac OS X 10.13 (High Sierra)
Mac OS X 10.14 (Mojave)
Mac OS X 10.15 (Catalina)
Mac OS X 11 Beta (Big Sur)
Adobe Acrobat 11

Comparison sheet

20.1 comparison

20.1 2 comparison

20.1 3 comparison

20.1 4 comparison


Please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it. for a 14-day free trial.

Tips and Trix

Click on the following links to view short videos highlighting: All Current Tips & Tricks in ChemDraw.

If you are one of the 1+ million people who love ChemDraw® from PerkinElmer, these hacks are for you. Download all five tips in a single file and make your chemical drawings faster and more beautiful.

5cd hacks

Training and events

Upcoming trainings and events can be found at:


If the answer is not on the product page, please contact us via our support form.

Please describe your problem in as much detail as possible when contacting our support.

Remember to always inform about which product version you have and which operating system you use (both platform and version).

You can also visit the links below for help
Perkin Elmer Support